2-Interleukina (IL-2) eta IL-15 seinalizazio bidezidorrak T linfozitoetan: antzekoak baina aldiberean ezberdinak
نویسندگان
چکیده
منابع مشابه
Whole Tumor Cell Vaccine Adjuvants: Comparing IL-12 to IL-2 and IL-15
Cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. Several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. Cancer vaccines induce pe...
متن کاملIL-2, IL-15 and IL-21 expand T cells for targeted adoptive therapy
Background Expansion of antigen-specific T cells, from peripheral blood specific for tumor-associated antigens (TAAs) is a prerequisite for the advanced cellular therapy. Such antigen-specific T cells should express a Th1-functional phenotype and are able to enter tumor-tissue. We identified a cytokine cocktail, comprised of IL-2, IL-15 and IL-21 that drives antigen-specific T cells from periph...
متن کاملwhole tumor cell vaccine adjuvants: comparing il-12 to il-2 and il-15
cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. cancer vaccines induce pe...
متن کاملQuantitative analysis of IL - 2 and IL - 15 signal transduction in T lymphocytes
..............................................................................................................................3 Acknow ledgem ents...................................................................................................... 5 Chapter 1: Introduction and Background............................................................... 15 References..................................
متن کاملTCR-independent activation of extrathymically developed, self antigen-specific T cells by IL-2/IL-15.
Naive intrathymically developed T cells, which express foreign Ag-specific TCR, do not express IL-2R. After antigenic stimulation, they express high affinity IL-2R, which enables IL-2 to be used as an autocrine growth factor. On the contrary, extrathymically developed T cells, which express self Ag-specific TCR but are unresponsive to antigenic stimulation, spontaneously express low affinity IL...
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ژورنال
عنوان ژورنال: EKAIA Euskal Herriko Unibertsitateko Zientzi eta Teknologi Aldizkaria
سال: 2016
ISSN: 0214-9001
DOI: 10.1387/ekaia.14584